George Shopp, PhD, DABT 

Dr. George Shopp, PhD DABT, is a private consultant assisting clients in the nonclinical discovery and development of small molecule and biological therapeutics.  He has 28 years experience in the fields of toxicology, pharmacology, pharmacokinetics and drug development.  This includes two years at toxicology contract research organizations (CROs), 12 years in grant and contract supported basic and applied research (Medical College of Virginia and Lovelace Medical Foundation).  Fourteen years in industrial drug development including: 3 years at Synergen responsible for all regulatory and research/ investigational toxicology; 2 years at Genentech directing the research toxicology group, and responsible for nonclinical development of growth factors and monoclonal antibodies; and Elan Pharmaceuticals for 9 years responsible for global nonclinical development and research toxicology of small molecule drugs and biopharmaceutics.  Therapeutic areas include:  Alzheimer’s disease, Parkinson’s disease, pain, migraine, oncology, diabetes, epilepsy, stroke, rheumatoid arthritis, inflammatory bowel disease, and sepsis.  Drug classes include: enzyme inhibitors, ion channel blockers, anti-angiogenesis factors, growth factors, monoclonal antibodies, human proteins, and polyethylene glycol conjugated molecules. 

Areas of expertise include: building and managing skilled and efficient nonclinical safety groups in the pharmaceutical industry, global nonclinical development of small molecule and protein drugs, regulatory toxicology (FDA, EU and Japan), performing due diligence on potential inlicensed programs, conducting inhouse and contract GLP pharmacology/toxicology/ADME/PK studies, in vitro toxicity testing and screening, in vivo disease models, research and investigational toxicology, assessment of immunotoxicologic/host resistance/hematopoietic effects of drugs and chemicals, flow cytometry, and pulmonary toxicology/immunology.  Dr. Shopp was President of the Board of Directors for the American Board of Toxicology in 2003.

The full CV is here